Osteogenesis+Imperfecta

=All About Osteogenesis Imperfecta (OI)= by Elizabeth and Mariana Osteogenesis imperfecta, also known as Brittle Bone Disease, is a disease that makes bones break very easily. The gene for OI is an autosomnal dominant gene, and is mostly passed down from parent to child, though it can also be an individual mutation. If someone has OI, their children will have a 50% chance of being born with it. If a child has OI, fractures will sometimes occur when they are born because of the OI, depending on the type. A person who has this disease will not have as much collagen,or have collagen of poorer quality than a normal person. Collagen is a kind of protein that is found in of the bones and makes them strong.There are four types of Osteogenesis Imperfecta.

Type I
Type I is the most common form of OI, and is considered to be the mildest type of the disease. People with Type I OI have less collagen than normal people and loose joints in their body.Their eyes protrude slightly, and the whites of their eyes, or sclera, are discolored, usually a gray blue color.Type I will sometimes give children bad hearing, and some people with OI have weak teeth as well.

Type II
Type II is believed to be the most severe of the types.Type II makes collagen of poor quality. Babies with this type of OI have broken bones even before birth, and are often stillborn or else die shortly after birth due to respiratory failures.

TypeIII
Type III is much like Type II, but less severe. Bone fractures before birth, bone deformities, respiratory problems, discolored sclera and short stature are all signs of Type III. The aproximate height of an adult who has Type III of OI is less than 4 feet high.

Type IV
Type IV of OI is considered to be moderate OI. People with this type of OI have some bone deformity, are short for their age, and have bowing in the bones of their legs. Their bones fracture easily, especially before puberty. They often die before age 25 because all of their organs are pushed together in a small, malformed body due to bones breaking so much. This puts strain on the heart and the person dies of a heart attack.

Other types of OI
There are two other types of OI, Type V and Type VI, but they are only distinguished from Type IV by the texture of the bones. Type V has bones with a "meshlike" bone appearance and Type VI has bones with a "fish-scale" bone appearence.

Citation
[|http://en.wikipedia.org/] http://www.oif.org/site/PageServer?pagename=FastFacts__]] [|http://orthoinfo.aaos.org]